METACHROMASIA INHIBITING COMPONENTS IN AMYLOID
نویسندگان
چکیده
منابع مشابه
Inhibiting transthyretin amyloid fibril formation via protein stabilization.
Transthyretin (TTR) amyloid fibril formation is observed systemically in familial amyloid polyneuropathy and senile systemic amyloidosis and appears to be the causative agent in these diseases. Herein, we demonstrate conclusively that thyroxine (10.8 microM) inhibits TTR fibril formation efficiently in vitro and does so by stabilizing the tetramer against dissociation and the subsequent conform...
متن کاملInhibiting transthyretin conformational changes that lead to amyloid fibril formation.
Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer's disease, familial amyloid polyneuropathy, and senile systemic amyloidosis. The latter two diseases are associated with transthyretin (TTR) amyloid fibrils, which appear to form in the acidic partial dena...
متن کاملFurther Studies on Metachromasia in Cultured Human Fibroblasts
Staining with Alcian blue in various concentrations of magnesium chloride (alcianophilia) has been found to be a useful supplement to metachromatic staining to detect increased cellular concentrations of glycosaminoglycans (mucopolysaccharides). In many instances alcianophilia at 0.3 M MgCl(2) is more specific than metachromasia and does not give "false positives" sometimes found in normal indi...
متن کاملNon-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils.
Amyloid deposits are proteinaceous extra-cellular aggregates associated with a diverse range of disease states. These deposits are composed predominantly of amyloid fibrils, the unbranched, beta-sheet rich structures that result from the misfolding and subsequent aggregation of many proteins. In addition, amyloid deposits contain a number of non-fibrillar components that interact with amyloid f...
متن کاملMetachromasia after treating tissue sections with sulphuric acid.
on the capacity of tissue elements to strain metachromatically. Surprising as it may seem, adequately fixed and dehydrated tissues withstand five minutes' immersion in concentrated sulphuric acid without charring or showing any severe disturbance of their structure. Subsequent staining with a metachromatic dye reveals that a greatly increased range of tissue elements shows a metachromatic affin...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1958
ISSN: 0022-1554,1551-5044
DOI: 10.1177/6.3.181